Try running the studio as an administrator (in Win7 right-click the studio icon and select the Run as administrator option).
If the above does not help, and you're sure there's no other process accessing the workspace files (particularly it's .metadata folder), then you should be able to workaround this by creating a new workspace (via File>Switch Workspace>Other...) and import your existing projects to it (via File>Import...>General>Existing Projects into Workspace - I suggest you check the Copy projects into workspace check box).
Regards,
David
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